BCL11A
Gene Ontology Biological Process
- B cell differentiation [IMP]
- T cell differentiation [IMP]
- negative regulation of collateral sprouting [ISO]
- negative regulation of dendrite development [ISO]
- negative regulation of gene expression [IMP]
- negative regulation of neuron projection development [ISO]
- negative regulation of nucleic acid-templated transcription [IDA]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of collateral sprouting [ISO]
- positive regulation of neuron projection development [ISO]
- protein sumoylation [IMP]
- regulation of dendrite development [ISO]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- transcription corepressor activity [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- transcription corepressor activity [IDA]
Gene Ontology Cellular Component
- nuclear body [IDA]
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
NR2E1
Gene Ontology Biological Process
- aggressive behavior [IMP]
- amygdala development [IMP]
- anterior commissure morphogenesis [IMP]
- behavioral fear response [IMP]
- brain development [IMP]
- camera-type eye development [IMP]
- cell fate commitment [IGI]
- cerebral cortex development [IMP]
- cerebral cortex neuron differentiation [IMP]
- dentate gyrus development [IMP]
- extracellular matrix organization [IMP]
- forebrain generation of neurons [IMP]
- glial cell migration [IMP]
- layer formation in cerebral cortex [IMP]
- long-term synaptic potentiation [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of astrocyte differentiation [IMP]
- negative regulation of neural precursor cell proliferation [IMP]
- negative regulation of neuron differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- olfactory bulb development [IMP]
- positive regulation of angiogenesis [IMP]
- positive regulation of cell cycle [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of neural precursor cell proliferation [IMP]
- positive regulation of stem cell proliferation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of cell migration involved in sprouting angiogenesis [IMP]
- regulation of cellular component organization [IMP]
- regulation of dendrite morphogenesis [IMP]
- regulation of timing of neuron differentiation [IMP]
- retina development in camera-type eye [IMP]
- social behavior [IMP]
- somatic stem cell maintenance [IMP]
- transcription from RNA polymerase II promoter [IMP]
- visual perception [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA, IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- enzyme binding [IPI]
- histone deacetylase binding [IPI]
- protein binding [IPI]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA, IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- enzyme binding [IPI]
- histone deacetylase binding [IPI]
- protein binding [IPI]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors.
Despite their physiological importance, selective interactions between nuclear receptors (NRs) and their cofactors are poorly understood. Here, we describe a novel signature motif (F/YSXXLXXL/Y) in the developmental regulator BCL11A that facilitates its selective interaction with members of the NR2E/F subfamily. Two copies of this motif (named here as RID1 and RID2) permit BCL11A to bind COUP-TFs (NR2F1;NR2F2;NR2F6) and Tailless/TLX (NR2E1), ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID