BAIT
SIRT2
5730427M03Rik, SIR2L2, Sir2l
sirtuin 2
GO Process (46)
GO Function (14)
GO Component (23)
Gene Ontology Biological Process
- cellular lipid catabolic process [IMP]
- cellular response to caloric restriction [IDA]
- cellular response to epinephrine stimulus [IDA]
- cellular response to hepatocyte growth factor stimulus [ISO]
- cellular response to hypoxia [ISO]
- cellular response to molecule of bacterial origin [ISO]
- cellular response to oxidative stress [IDA]
- hepatocyte growth factor receptor signaling pathway [ISO]
- histone H3 deacetylation [IMP, ISO]
- histone H4 deacetylation [IMP, ISO]
- histone deacetylation [IGI]
- myelination in peripheral nervous system [IMP, ISO]
- negative regulation of NLRP3 inflammasome complex assembly [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of autophagy [ISO]
- negative regulation of cell proliferation [IMP, ISO]
- negative regulation of defense response to bacterium [IMP, ISO]
- negative regulation of fat cell differentiation [IMP]
- negative regulation of oligodendrocyte differentiation [ISO]
- negative regulation of oligodendrocyte progenitor proliferation [ISO]
- negative regulation of peptidyl-threonine phosphorylation [IMP]
- negative regulation of protein catabolic process [ISO]
- negative regulation of reactive oxygen species metabolic process [IMP]
- negative regulation of striated muscle tissue development [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- peptidyl-lysine deacetylation [ISO]
- phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of DNA binding [IDA]
- positive regulation of attachment of spindle microtubules to kinetochore [IMP]
- positive regulation of cell division [IMP]
- positive regulation of execution phase of apoptosis [IMP]
- positive regulation of meiosis [IMP]
- positive regulation of oocyte maturation [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein deacetylation [IDA, IMP, ISO]
- protein kinase B signaling [ISO]
- regulation of cell cycle [ISO]
- regulation of fat cell differentiation [IMP]
- regulation of myelination [IMP, ISO]
- ripoptosome assembly involved in necroptotic process [IMP]
- tubulin deacetylation [IGI, IMP, ISO]
Gene Ontology Molecular Function- NAD+ binding [ISO]
- NAD-dependent histone deacetylase activity (H4-K16 specific) [ISO]
- NAD-dependent protein deacetylase activity [ISO]
- beta-tubulin binding [IDA]
- chromatin binding [ISO]
- histone acetyltransferase binding [ISO]
- histone deacetylase activity [IMP, ISO]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein deacetylase activity [IDA, IMP, ISO]
- transcription factor binding [IPI, ISO]
- tubulin deacetylase activity [IMP, ISO]
- ubiquitin binding [ISO]
- zinc ion binding [ISO]
- NAD+ binding [ISO]
- NAD-dependent histone deacetylase activity (H4-K16 specific) [ISO]
- NAD-dependent protein deacetylase activity [ISO]
- beta-tubulin binding [IDA]
- chromatin binding [ISO]
- histone acetyltransferase binding [ISO]
- histone deacetylase activity [IMP, ISO]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein deacetylase activity [IDA, IMP, ISO]
- transcription factor binding [IPI, ISO]
- tubulin deacetylase activity [IMP, ISO]
- ubiquitin binding [ISO]
- zinc ion binding [ISO]
Gene Ontology Cellular Component
- Schmidt-Lanterman incisure [IDA, ISO]
- centriole [ISO]
- centrosome [ISO]
- chromosome [ISO]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- glial cell projection [ISO]
- juxtaparanode region of axon [ISO]
- lateral loop [ISO]
- meiotic spindle [IDA]
- microtubule [ISO]
- midbody [IDA, ISO]
- mitotic spindle [ISO]
- myelin sheath [IDA, ISO]
- myelin sheath abaxonal region [ISO]
- nuclear heterochromatin [ISO]
- nucleus [IDA, ISO]
- paranodal junction [IDA, ISO]
- paranode region of axon [ISO]
- perikaryon [IDA, ISO]
- perinuclear region of cytoplasm [IDA]
- spindle [ISO]
- terminal loop [ISO]
Mus musculus
PREY
EP300
KAT3B, RSTS2, p300, RP1-85F18.1
E1A binding protein p300
GO Process (29)
GO Function (15)
GO Component (3)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- N-terminal peptidyl-lysine acetylation [IDA]
- Notch signaling pathway [TAS]
- apoptotic process [IMP]
- cellular response to hypoxia [TAS]
- chromatin organization [TAS]
- circadian rhythm [ISS]
- histone H2B acetylation [IDA]
- histone H4 acetylation [IMP]
- innate immune response [TAS]
- internal peptidyl-lysine acetylation [IDA]
- internal protein amino acid acetylation [IDA]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IDA]
- mitotic cell cycle [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- nervous system development [TAS]
- positive regulation by host of viral transcription [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response [ISS]
- positive regulation of type I interferon production [TAS]
- protein stabilization [ISS]
- regulation of androgen receptor signaling pathway [IDA]
- regulation of cell cycle [TAS]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- regulation of transcription, DNA-templated [IDA]
- regulation of tubulin deacetylation [IDA]
- response to estrogen [IDA]
- response to hypoxia [IDA]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II activating transcription factor binding [IPI]
- acetyltransferase activity [IDA, IMP]
- activating transcription factor binding [IPI]
- androgen receptor binding [IPI]
- beta-catenin binding [IPI]
- chromatin binding [IMP]
- core promoter binding [IDA]
- histone acetyltransferase activity [IDA]
- lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [IDA]
- nuclear hormone receptor binding [IPI]
- protein binding [IPI]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- transferase activity, transferring acyl groups [IDA]
- DNA binding [IDA]
- RNA polymerase II activating transcription factor binding [IPI]
- acetyltransferase activity [IDA, IMP]
- activating transcription factor binding [IPI]
- androgen receptor binding [IPI]
- beta-catenin binding [IPI]
- chromatin binding [IMP]
- core promoter binding [IDA]
- histone acetyltransferase activity [IDA]
- lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [IDA]
- nuclear hormone receptor binding [IPI]
- protein binding [IPI]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- transferase activity, transferring acyl groups [IDA]
Homo sapiens
Biochemical Activity (Deacetylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1.
The SIR2 family of nicotinamide adenosine dinucleotide (NAD)-dependent deacetylases modulates diverse biological functions in different species, including longevity, apoptosis, cell cycle exit, and cellular differentiation. SIRT1, the closest mammalian ortholog of the yeast SIR2 (silent information regulator 2) gene, represses several transcription factors, including p53, NFkappaB and forkhead proteins. The p300 protein serves as a rate-limiting transcriptional cointegrator of diverse ... [more]
J. Biol. Chem. Mar. 18, 2005; 280(11);10264-76 [Pubmed: 15632193]
Throughput
- Low Throughput
Curated By
- BioGRID