Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex.

Publication

Structural studies of the SET domain from RIZ1 tumor suppressor.

Briknarova K, Zhou X, Satterthwait A, Hoyt DW, Ely KR, Huang S

RIZ1 is a transcriptional regulator and tumor suppressor that catalyzes methylation of lysine 9 of histone H3. It contains a distinct SET domain, sometimes referred to as PR (PRDI-BF1 and RIZ1 homology) domain, that is responsible for its catalytic activity. We determined the solution structure of the PR domain from RIZ1 and characterized its interaction with S-adenosyl-l-homocysteine (SAH) and a ... [more]

Biochem. Biophys. Res. Commun. Feb. 15, 2008; 366(3);807-13 [Pubmed: 18082620]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

PRDM2

Gene Ontology Biological Process

Gene Ontology Molecular Function

sequence-specific DNA binding transcription factor activity [NAS]zinc ion binding [NAS]

Gene Ontology Cellular Component

HIST3H3