BAIT

CIAO1

CIA1, WDR39
cytosolic iron-sulfur assembly component 1
UPS Project
Homo sapiens
PREY

PLEKHA5

PEPP-2, PEPP2
pleckstrin homology domain containing, family A member 5
GO Process (0)
GO Function (2)
GO Component (1)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins.

Stehling O, Mascarenhas J, Vashisht AA, Sheftel AD, Niggemeyer B, Roesser R, Pierik AJ, Wohlschlegel JA, Lill R

Numerous cytosolic and nuclear proteins involved in metabolism, DNA maintenance, protein translation, or iron homeostasis depend on iron-sulfur (Fe/S) cofactors, yet their assembly is poorly defined. Here, we identify and characterize human CIA2A (FAM96A), CIA2B (FAM96B), and CIA1 (CIAO1) as components of the cytosolic Fe/S protein assembly (CIA) machinery. CIA1 associates with either CIA2A or CIA2B and the CIA-targeting factor ... [more]

Cell Metab. Aug. 06, 2013; 18(2);187-98 [Pubmed: 23891004]

Throughput

  • High Throughput

Curated By

  • BioGRID