PRNP
Gene Ontology Biological Process
- cellular copper ion homeostasis [TAS]
- cellular response to copper ion [ISO]
- cellular response to drug [IDA]
- learning or memory [ISO]
- negative regulation of T cell receptor signaling pathway [IMP]
- negative regulation of activated T cell proliferation [IMP]
- negative regulation of apoptotic process [IGI, ISO]
- negative regulation of calcineurin-NFAT signaling cascade [IMP]
- negative regulation of interferon-gamma production [IMP]
- negative regulation of interleukin-17 production [IMP]
- negative regulation of interleukin-2 production [IMP]
- negative regulation of protein phosphorylation [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IMP]
- nucleobase-containing compound metabolic process [TAS]
- regulation of potassium ion transmembrane transport [IGI]
- regulation of protein localization [IMP]
- response to cadmium ion [ISO]
- response to copper ion [ISO]
- response to oxidative stress [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DPP6
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6.
Widely expressed in the adult central nervous system, the cellular prion protein (PrP(C)) is implicated in a variety of processes, including neuronal excitability. Dipeptidyl aminopeptidase-like protein 6 (DPP6) was first identified as a PrP(C) interactor using in vivo formaldehyde cross-linking of wild type (WT) mouse brain. This finding was confirmed in three cell lines and, because DPP6 directs the functional ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PRNP DPP6 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - | |
| DPP6 PRNP | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| PRNP DPP6 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.8355 | BioGRID | 2668701 |
Curated By
- BioGRID