BAIT
KIF1A
ATSV, C2orf20, HSN2C, MRD9, SPG30, UNC104
kinesin family member 1A
GO Process (6)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RFX6
MTCHRS, MTFS, RFXDC1, dJ955L16.1, RP5-955L16.1
regulatory factor X, 6
GO Process (10)
GO Function (6)
GO Component (1)
Gene Ontology Biological Process
- endocrine pancreas development [IMP]
- glucose homeostasis [IMP]
- pancreatic A cell differentiation [IBA, ISS]
- pancreatic D cell differentiation [IBA, ISS]
- pancreatic epsilon cell differentiation [IBA, ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of insulin secretion [IMP]
- regulation of transcription from RNA polymerase II promoter [IBA]
- type B pancreatic cell differentiation [IBA, ISS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IBA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IBA]
- transcription regulatory region DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IBA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IBA]
- transcription regulatory region DNA binding [IDA]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.
Increased risk for autism spectrum disorders (ASD) is attributed to hundreds of genetic loci. The convergence of ASD variants have been investigated using various approaches, including protein interactions extracted from the published literature. However, these datasets are frequently incomplete, carry biases and are limited to interactions of a single splicing isoform, which may not be expressed in the disease-relevant tissue. ... [more]
Nat Commun Apr. 12, 2014; 5(0);3650 [Pubmed: 24722188]
Throughput
- High Throughput
Curated By
- BioGRID