BAIT
SEPT5
CDCREL, CDCREL-1, CDCREL1, H5, HCDCREL-1, PNUTL1
septin 5
GO Process (5)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
MYOG
MYF4, bHLHc3, myf-4
myogenin (myogenic factor 4)
GO Process (19)
GO Function (8)
GO Component (4)
Gene Ontology Biological Process
- cellular response to estradiol stimulus [ISS]
- mRNA transcription from RNA polymerase II promoter [TAS]
- muscle cell differentiation [TAS]
- muscle cell fate commitment [ISS]
- negative regulation of cell proliferation [ISS]
- positive regulation of cell cycle arrest [ISS]
- positive regulation of muscle atrophy [ISS]
- positive regulation of muscle cell differentiation [TAS]
- positive regulation of myoblast differentiation [ISS]
- positive regulation of myotube differentiation [ISS]
- positive regulation of skeletal muscle fiber development [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISS]
- regulation of myoblast fusion [ISS]
- regulation of satellite cell proliferation [ISS]
- response to denervation involved in regulation of muscle adaptation [ISS]
- response to electrical stimulus involved in regulation of muscle adaptation [ISS]
- response to muscle activity involved in regulation of muscle adaptation [ISS]
- skeletal muscle tissue development [TAS]
- striated muscle atrophy [ISS]
Gene Ontology Molecular Function- E-box binding [ISS]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA, ISS]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, TAS]
- chromatin DNA binding [ISS]
- core promoter binding [ISS]
- protein heterodimerization activity [ISS]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [ISS]
- E-box binding [ISS]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA, ISS]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, TAS]
- chromatin DNA binding [ISS]
- core promoter binding [ISS]
- protein heterodimerization activity [ISS]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [ISS]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.
Increased risk for autism spectrum disorders (ASD) is attributed to hundreds of genetic loci. The convergence of ASD variants have been investigated using various approaches, including protein interactions extracted from the published literature. However, these datasets are frequently incomplete, carry biases and are limited to interactions of a single splicing isoform, which may not be expressed in the disease-relevant tissue. ... [more]
Nat Commun Apr. 12, 2014; 5(0);3650 [Pubmed: 24722188]
Throughput
- High Throughput
Curated By
- BioGRID