CD44
Gene Ontology Biological Process
- blood coagulation [TAS]
- carbohydrate metabolic process [TAS]
- cartilage development [IEP]
- cell-matrix adhesion [NAS]
- cellular response to fibroblast growth factor stimulus [IDA]
- cytokine-mediated signaling pathway [TAS]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- glycosaminoglycan metabolic process [TAS]
- hyaluronan catabolic process [IDA, TAS]
- hyaluronan metabolic process [TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- leukocyte migration [TAS]
- monocyte aggregation [IMP]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [IDA]
- negative regulation of apoptotic process [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of heterotypic cell-cell adhesion [IMP]
- positive regulation of monocyte aggregation [IMP]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- single organismal cell-cell adhesion [NAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NF2
Gene Ontology Biological Process
- Schwann cell proliferation [IMP]
- actin cytoskeleton organization [IMP]
- negative regulation of DNA replication [IMP]
- negative regulation of JAK-STAT cascade [IDA]
- negative regulation of cell migration [TAS]
- negative regulation of cell proliferation [IDA, IMP]
- negative regulation of cell-cell adhesion [IDA]
- negative regulation of cell-matrix adhesion [TAS]
- negative regulation of tyrosine phosphorylation of Stat3 protein [IDA]
- negative regulation of tyrosine phosphorylation of Stat5 protein [IDA]
- positive regulation of stress fiber assembly [IMP]
- regulation of hippo signaling [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
Structural basis of DDB1-and-Cullin 4-associated Factor 1 (DCAF1) recognition by merlin/NF2 and its implication in tumorigenesis by CD44-mediated inhibition of merlin suppression of DCAF1 function.
Merlin, a tumor suppressor encoded by the neurofibromatosis type 2 gene, has been shown to suppress tumorigenesis by inhibiting the Cullin 4-RING E3 ubiquitin ligase CRL4(DCAF) (1) in the nucleus. This inhibition is mediated by direct binding of merlin to DDB1-and-Cullin 4-associated Factor 1 (DCAF1), yet the binding mode of merlin to DCAF1 is not well defined. Here, we report ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NF2 CD44 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| CD44 NF2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 331418 | |
| NF2 CD44 | FRET FRET An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins. | High | - | BioGRID | 2640793 | |
| CD44 NF2 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID