BAIT

SPRTN

C1orf124, DDDL1880, DVC1, PRO4323, Spartan, dJ876B10.3, RP5-876B10.3
SprT-like N-terminal domain
UPS Project
GO Process (4)
GO Function (3)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

AKAP12

AKAP250, SSeCKS
A kinase (PRKA) anchor protein 12
GO Process (3)
GO Function (2)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Regulation of error-prone translesion synthesis by Spartan/C1orf124.

Kim MS, Machida Y, Vashisht AA, Wohlschlegel JA, Pang YP, Machida YJ

Translesion synthesis (TLS) employs low fidelity polymerases to replicate past damaged DNA in a potentially error-prone process. Regulatory mechanisms that prevent TLS-associated mutagenesis are unknown; however, our recent studies suggest that the PCNA-binding protein Spartan plays a role in suppression of damage-induced mutagenesis. Here, we show that Spartan negatively regulates error-prone TLS that is dependent on POLD3, the accessory subunit ... [more]

Nucleic Acids Res. Feb. 01, 2013; 41(3);1661-8 [Pubmed: 23254330]

Throughput

  • Low Throughput

Curated By

  • BioGRID