BAIT
SPRTN
C1orf124, DDDL1880, DVC1, PRO4323, Spartan, dJ876B10.3, RP5-876B10.3
SprT-like N-terminal domain
GO Process (4)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
LMNB1
ADLD, LMN, LMN2, LMNB
lamin B1
GO Process (2)
GO Function (0)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Regulation of error-prone translesion synthesis by Spartan/C1orf124.
Translesion synthesis (TLS) employs low fidelity polymerases to replicate past damaged DNA in a potentially error-prone process. Regulatory mechanisms that prevent TLS-associated mutagenesis are unknown; however, our recent studies suggest that the PCNA-binding protein Spartan plays a role in suppression of damage-induced mutagenesis. Here, we show that Spartan negatively regulates error-prone TLS that is dependent on POLD3, the accessory subunit ... [more]
Nucleic Acids Res. Feb. 01, 2013; 41(3);1661-8 [Pubmed: 23254330]
Throughput
- Low Throughput
Curated By
- BioGRID