MAPRE1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TRIO
Gene Ontology Biological Process
- apoptotic signaling pathway [TAS]
- axon guidance [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of GTPase activity [TAS]
- positive regulation of apoptotic process [TAS]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
- transmembrane receptor protein tyrosine phosphatase signaling pathway [TAS]
Gene Ontology Molecular Function
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Dynamic Microtubules Catalyze Formation of Navigator-TRIO Complexes to Regulate Neurite Extension.
Neurite extension is regulated by multiple signaling cascades that ultimately converge on the actin and microtubule networks [1]. Rho GTPases, molecular switches that oscillate between an inactive, GDP-bound state and an active, GTP-bound state, play a pivotal role in controlling actin cytoskeleton dynamics in the growth cone [2], whereas the dynamic behavior and interactions of microtubules are largely regulated by ... [more]
Throughput
- Low Throughput
Additional Notes
- interaction enhanced in the presence of Nav1
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MAPRE1 TRIO | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 3359750 | |
| MAPRE1 TRIO | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | 96.25 | BioGRID | 2995782 |
Curated By
- BioGRID