IKBKG
Gene Ontology Biological Process
- B cell homeostasis [IMP]
- activation of NF-kappaB-inducing kinase activity [IDA]
- cellular response to DNA damage stimulus [ISO]
- establishment of vesicle localization [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IBA, ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- K63-linked polyubiquitin binding [IDA]
- linear polyubiquitin binding [ISO]
- peroxisome proliferator activated receptor binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- ubiquitin protein ligase binding [ISO]
- K63-linked polyubiquitin binding [IDA]
- linear polyubiquitin binding [ISO]
- peroxisome proliferator activated receptor binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
RHOA
Gene Ontology Biological Process
- GTP catabolic process [IDA, ISO]
- Rho protein signal transduction [TAS]
- actin cytoskeleton organization [IDA]
- androgen receptor signaling pathway [IDA]
- apical junction assembly [IDA, ISO]
- apolipoprotein A-I-mediated signaling pathway [ISO]
- cell adhesion [IMP]
- cell differentiation [IDA]
- cell morphogenesis [IGI]
- cell-matrix adhesion [IDA]
- cerebral cortex cell migration [IMP]
- cleavage furrow formation [ISO]
- cytoskeleton organization [IMP]
- forebrain radial glial cell differentiation [IMP]
- integrin-mediated signaling pathway [TAS]
- negative chemotaxis [ISO]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- negative regulation of cell death [ISO]
- negative regulation of intracellular steroid hormone receptor signaling pathway [IDA]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of neuron differentiation [ISO]
- ossification involved in bone maturation [IMP]
- positive regulation of actin filament polymerization [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of cytokinesis [ISO]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of neuron differentiation [ISO]
- positive regulation of podosome assembly [IGI]
- positive regulation of smooth muscle contraction [ISO]
- positive regulation of stress fiber assembly [ISO]
- regulation of calcium ion transport [ISO]
- regulation of cell migration [ISO]
- regulation of dendrite development [ISO]
- regulation of neural precursor cell proliferation [IMP]
- regulation of neuron projection development [IDA]
- regulation of osteoblast proliferation [IMP]
- regulation of transcription from RNA polymerase II promoter [IDA]
- response to drug [ISO]
- skeletal muscle tissue development [IDA]
- spindle assembly involved in mitosis [ISO]
- stress fiber assembly [IDA]
- stress-activated protein kinase signaling cascade [ISO]
- trabecula morphogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
IκB kinase γ/nuclear factor-κB-essential modulator (IKKγ/NEMO) facilitates RhoA GTPase activation, which, in turn, activates Rho-associated KINASE (ROCK) to phosphorylate IKKβ in response to transforming growth factor (TGF)-β1.
Transforming growth factor (TGF)-β1 plays several roles in a variety of cellular functions. TGF-β1 transmits its signal through Smad transcription factor-dependent and -independent pathways. It was reported that TGF-β1 activates NF-κB and RhoA, and RhoA activates NF-κB in several kinds of cells in a Smad-independent pathway. However, the activation molecular mechanism of NF-κB by RhoA upon TGF-β1 has not been ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID