NUP159
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NAB2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
Nucleoporin FG Domains Facilitate mRNP Remodeling at the Cytoplasmic Face of the Nuclear Pore Complex.
Directional export of mRNA-protein particles (mRNPs) through nuclear pore complexes (NPCs) requires multiple factors. In Saccharomyces cerevisiae, the NPC proteins Nup159 and Nup42 are asymmetrically localized to the cytoplasmic face and have distinct functional domains: a phenylalanine-glycine (FG) repeat domain that docks mRNP transport receptors, and domains that bind the DEAD-box ATPase Dbp5 and its activating cofactor Gle1, respectively. We ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: cold sensitivity (APO:0000148)
- phenotype: vegetative growth (APO:0000106)
Additional Notes
- Figure 3
- genetic complex
- nab2-C437S mutation partially rescues cold-sensitivity of nup159-deltaFG nup42-deltaFG double mutant
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
NAB2 NUP159 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 2907404 | |
NAB2 NUP159 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 463181 | |
NAB2 NUP159 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.3661 | BioGRID | 1933336 |
Curated By
- BioGRID