BAIT
AKT2
2410016A19Rik, AW554154, PKB, PKBbeta
thymoma viral proto-oncogene 2
GO Process (30)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- activation of Ral GTPase activity [IGI]
- cellular response to insulin stimulus [IDA, ISO]
- cellular response to organic cyclic compound [ISO]
- insulin receptor signaling pathway [IDA, ISO]
- intracellular protein transmembrane transport [IMP]
- negative regulation of RNA splicing [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of plasma membrane long-chain fatty acid transport [ISO]
- peripheral nervous system myelin maintenance [IMP]
- positive regulation of cell migration [ISO]
- positive regulation of cell motility [ISO]
- positive regulation of fatty acid beta-oxidation [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of glucose import [ISO]
- positive regulation of glucose import in response to insulin stimulus [IGI]
- positive regulation of glucose metabolic process [ISO]
- positive regulation of glycogen biosynthetic process [ISO]
- positive regulation of nitric oxide biosynthetic process [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of positive chemotaxis [ISO]
- positive regulation of protein phosphorylation [IDA, ISO]
- positive regulation of protein targeting to membrane [IMP]
- positive regulation of signal transduction [ISO]
- positive regulation of sodium ion transport [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of vesicle fusion [IMP]
- protein kinase B signaling [ISO]
- protein localization to plasma membrane [IGI]
- protein phosphorylation [IDA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
KCTD20
2410004N11Rik, AI451943, AW541186, D17Ertd562e, RP24-318I24.4
potassium channel tetramerisation domain containing 20
GO Process (1)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
KCTD20, a relative of BTBD10, is a positive regulator of Akt.
BTBD10 binds to Akt and protein phosphatase 2A (PP2A) and inhibits the PP2A-mediated dephosphorylation of Akt, thereby keeping Akt activated. Previous studies have suggested that BTBD10 plays an important role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells. Because levels of BTBD10 expression are much lower in many non-nervous tissues than nervous tissues, there may ... [more]
BMC Biochem. Oct. 26, 2013; 14(0);27 [Pubmed: 24156551]
Throughput
- Low Throughput
Curated By
- BioGRID