BAIT
SNAI2
SLUG, SLUGH1, SNAIL2, WS2D
snail family zinc finger 2
GO Process (29)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- Notch signaling pathway [IMP]
- canonical Wnt signaling pathway [IMP]
- cell migration involved in endocardial cushion formation [ISS]
- cellular response to epidermal growth factor stimulus [IDA]
- desmosome disassembly [IMP]
- epithelial to mesenchymal transition [IMP]
- epithelial to mesenchymal transition involved in endocardial cushion formation [ISS]
- epithelium development [ISS]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [IMP]
- negative regulation of anoikis [IMP]
- negative regulation of canonical Wnt signaling pathway [IDA, IMP]
- negative regulation of catenin import into nucleus [IDA]
- negative regulation of cell adhesion mediated by integrin [IC]
- negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of chondrocyte differentiation [IMP]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISS]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [IMP]
- negative regulation of keratinocyte proliferation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of vitamin D biosynthetic process [IDA]
- negative regulation of vitamin D receptor signaling pathway [IDA]
- neural crest cell development [IMP]
- osteoblast differentiation [IEP]
- pigmentation [IMP]
- positive regulation of cell migration [IMP]
- regulation of chemokine production [IMP]
- regulation of osteoblast differentiation [IMP]
- regulation of tight junction assembly [IMP]
- sensory perception of sound [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PSMD1
P112, Rpn2, S1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
GO Process (21)
GO Function (0)
GO Component (7)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [TAS]
- G1/S transition of mitotic cell cycle [TAS]
- RNA metabolic process [TAS]
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- apoptotic process [TAS]
- cellular nitrogen compound metabolic process [TAS]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- mitotic cell cycle [TAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- protein polyubiquitination [TAS]
- regulation of apoptotic process [TAS]
- regulation of cellular amino acid metabolic process [TAS]
- regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- small molecule metabolic process [TAS]
- viral process [TAS]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
GSK3β controls epithelial-mesenchymal transition and tumor metastasis by CHIP-mediated degradation of Slug.
Glycogen synthase kinase 3 beta (GSK3β) is highly inactivated in epithelial cancers and is known to inhibit tumor migration and invasion. The zinc-finger-containing transcriptional repressor, Slug, represses E-cadherin transcription and enhances epithelial-mesenchymal transition (EMT). In this study, we find that the GSK3β-pSer9 level is associated with the expression of Slug in non-small cell lung cancer. GSK3β-mediated phosphorylation of Slug facilitates ... [more]
Oncogene Jun. 12, 2014; 33(24);3172-82 [Pubmed: 23851495]
Throughput
- High Throughput
Curated By
- BioGRID