BAIT
STXBP5L
LLGL4
syntaxin binding protein 5-like
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
STOML2
stomatin (Epb7.2)-like 2
GO Process (15)
GO Function (1)
GO Component (11)
Gene Ontology Biological Process
- CD4-positive, alpha-beta T cell activation [ISO, ISS]
- T cell receptor signaling pathway [ISO, ISS]
- cellular calcium ion homeostasis [ISO, ISS]
- interleukin-2 production [ISO, ISS]
- lipid localization [ISO, ISS]
- mitochondrial ATP synthesis coupled proton transport [ISO, ISS]
- mitochondrial calcium ion transport [ISO, ISS]
- mitochondrial protein processing [ISO, ISS]
- mitochondrion localization [ISO]
- mitochondrion organization [ISO, ISS]
- positive regulation of cardiolipin metabolic process [ISO, ISS]
- positive regulation of mitochondrial DNA replication [ISO, ISS]
- positive regulation of mitochondrial membrane potential [ISO, ISS]
- protein oligomerization [ISO, ISS]
- stress-induced mitochondrial fusion [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- COP9 signalosome [ISO]
- T cell receptor complex [ISO, ISS]
- actin cytoskeleton [ISO, ISS]
- cell [ISO]
- extrinsic component of plasma membrane [ISO, ISS]
- immunological synapse [ISO, ISS]
- intracellular [ISO]
- membrane raft [ISO, ISS]
- mitochondrial inner membrane [ISO, ISS]
- mitochondrial intermembrane space [ISO, ISS]
- mitochondrion [ISO]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Phosphorylation and Degradation of Tomosyn-2 De-represses Insulin Secretion.
The abundance and functional activity of proteins involved in the formation of the SNARE complex are tightly regulated for efficient exocytosis. Tomosyn proteins are negative regulators of exocytosis. Tomosyn causes an attenuation of insulin secretion by limiting the formation of the SNARE complex. We hypothesized that glucose-dependent stimulation of insulin secretion from β-cells must involve reversing the inhibitory action of ... [more]
J. Biol. Chem. Jul. 07, 2014; 0(0); [Pubmed: 25002582]
Throughput
- High Throughput
Curated By
- BioGRID