BAIT
STXBP5L
LLGL4
syntaxin binding protein 5-like
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
PURB
pur-beta
purine rich element binding protein B
GO Process (3)
GO Function (12)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function- RNA binding [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- SMAD binding [ISO]
- double-stranded DNA binding [ISO]
- mRNA binding [ISO, ISS]
- poly(A) RNA binding [ISO]
- purine-rich negative regulatory element binding [IDA]
- sequence-specific DNA binding transcription factor activity [ISO]
- single-stranded DNA binding [IDA, ISO, ISS]
- transcription factor binding [ISO, ISS]
- translation repressor activity, nucleic acid binding [IDA]
- RNA binding [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- SMAD binding [ISO]
- double-stranded DNA binding [ISO]
- mRNA binding [ISO, ISS]
- poly(A) RNA binding [ISO]
- purine-rich negative regulatory element binding [IDA]
- sequence-specific DNA binding transcription factor activity [ISO]
- single-stranded DNA binding [IDA, ISO, ISS]
- transcription factor binding [ISO, ISS]
- translation repressor activity, nucleic acid binding [IDA]
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Phosphorylation and Degradation of Tomosyn-2 De-represses Insulin Secretion.
The abundance and functional activity of proteins involved in the formation of the SNARE complex are tightly regulated for efficient exocytosis. Tomosyn proteins are negative regulators of exocytosis. Tomosyn causes an attenuation of insulin secretion by limiting the formation of the SNARE complex. We hypothesized that glucose-dependent stimulation of insulin secretion from β-cells must involve reversing the inhibitory action of ... [more]
J. Biol. Chem. Jul. 07, 2014; 0(0); [Pubmed: 25002582]
Throughput
- High Throughput
Curated By
- BioGRID