BAIT
STXBP5L
LLGL4
syntaxin binding protein 5-like
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
RAB3A
RAB3
RAB3A, member RAS oncogene family
GO Process (23)
GO Function (9)
GO Component (13)
Gene Ontology Biological Process
- GTP catabolic process [IBA, ISO]
- Rab protein signal transduction [IBA, IC]
- axonogenesis [ISO]
- intracellular protein transport [IBA]
- lung development [ISO]
- maintenance of presynaptic active zone structure [ISO]
- mitochondrion organization [ISO]
- neuromuscular synaptic transmission [ISO]
- positive regulation of ATPase activity [IDA]
- positive regulation of regulated secretory pathway [ISO]
- post-embryonic development [ISO]
- protein localization to plasma membrane [IBA]
- protein secretion [IBA]
- regulation of exocytosis [IBA, ISO]
- regulation of short-term neuronal synaptic plasticity [ISS]
- regulation of synaptic vesicle fusion to presynaptic membrane [ISO, ISS]
- respiratory system process [ISO]
- response to electrical stimulus [ISO]
- sensory perception of touch [ISO]
- synaptic vesicle exocytosis [IMP, ISO]
- synaptic vesicle maturation [ISO]
- synaptic vesicle recycling [IMP]
- vesicle docking involved in exocytosis [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Phosphorylation and Degradation of Tomosyn-2 De-represses Insulin Secretion.
The abundance and functional activity of proteins involved in the formation of the SNARE complex are tightly regulated for efficient exocytosis. Tomosyn proteins are negative regulators of exocytosis. Tomosyn causes an attenuation of insulin secretion by limiting the formation of the SNARE complex. We hypothesized that glucose-dependent stimulation of insulin secretion from β-cells must involve reversing the inhibitory action of ... [more]
J. Biol. Chem. Jul. 07, 2014; 0(0); [Pubmed: 25002582]
Throughput
- High Throughput
Curated By
- BioGRID