BAIT
STXBP5L
LLGL4
syntaxin binding protein 5-like
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
THY1
CD7
Thy-1 cell surface antigen
GO Process (18)
GO Function (6)
GO Component (14)
Gene Ontology Biological Process
- T cell receptor signaling pathway [IMP]
- angiogenesis [ISO, ISS]
- cytoskeleton organization [IDA]
- focal adhesion assembly [IDA]
- mast cell activation [NAS]
- negative regulation of T cell receptor signaling pathway [ISO, ISS]
- negative regulation of apoptotic process [TAS]
- negative regulation of axonogenesis [IDA]
- negative regulation of cell migration [IDA]
- negative regulation of fibroblast proliferation [NAS]
- negative regulation of protein kinase activity [IDA]
- positive regulation of GTPase activity [IDA]
- positive regulation of Rho GTPase activity [IDA]
- positive regulation of T cell activation [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [NAS]
- positive regulation of release of sequestered calcium ion into cytosol [IDA]
- retinal cone cell development [ISO, ISS]
- single organismal cell-cell adhesion [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- anchored component of external side of plasma membrane [ISO]
- anchored component of plasma membrane [IDA]
- apical plasma membrane [ISO]
- cell surface [IDA, TAS]
- cytosol [IDA]
- dendrite [ISO]
- endoplasmic reticulum [ISO]
- external side of plasma membrane [ISO, ISS]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- growth cone [IDA]
- membrane raft [ISO]
- myelin sheath [ISO]
- plasma membrane [IDA]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Phosphorylation and Degradation of Tomosyn-2 De-represses Insulin Secretion.
The abundance and functional activity of proteins involved in the formation of the SNARE complex are tightly regulated for efficient exocytosis. Tomosyn proteins are negative regulators of exocytosis. Tomosyn causes an attenuation of insulin secretion by limiting the formation of the SNARE complex. We hypothesized that glucose-dependent stimulation of insulin secretion from β-cells must involve reversing the inhibitory action of ... [more]
J. Biol. Chem. Jul. 07, 2014; 0(0); [Pubmed: 25002582]
Throughput
- High Throughput
Curated By
- BioGRID