BAIT

STXBP5L

LLGL4
syntaxin binding protein 5-like
UPS Project
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY

DYNLL2

Dlc2
dynein light chain LC8-type 2
GO Process (1)
GO Function (2)
GO Component (5)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Rattus norvegicus

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Phosphorylation and Degradation of Tomosyn-2 De-represses Insulin Secretion.

Bhatnagar S, Soni MS, Wrighton LS, Hebert AS, Zhou AS, Paul PK, Gregg T, Rabaglia ME, Keller MP, Coon JJ, Attie AD

The abundance and functional activity of proteins involved in the formation of the SNARE complex are tightly regulated for efficient exocytosis. Tomosyn proteins are negative regulators of exocytosis. Tomosyn causes an attenuation of insulin secretion by limiting the formation of the SNARE complex. We hypothesized that glucose-dependent stimulation of insulin secretion from β-cells must involve reversing the inhibitory action of ... [more]

J. Biol. Chem. Jul. 07, 2014; 0(0); [Pubmed: 25002582]

Throughput

  • High Throughput

Curated By

  • BioGRID