BAIT
STXBP5L
LLGL4
syntaxin binding protein 5-like
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
ATP1A2
RATATPA2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
GO Process (33)
GO Function (6)
GO Component (15)
Gene Ontology Biological Process
- ATP hydrolysis coupled proton transport [IMP]
- adult locomotory behavior [ISO]
- cardiac muscle contraction [IC]
- cellular potassium ion homeostasis [ISO]
- cellular response to mechanical stimulus [IDA, IEP]
- cellular response to steroid hormone stimulus [IMP, ISO]
- cellular sodium ion homeostasis [ISO]
- energy coupled proton transmembrane transport, against electrochemical gradient [TAS]
- locomotion [ISO]
- negative regulation of calcium ion transmembrane transport [IMP]
- negative regulation of calcium:sodium antiporter activity [IMP]
- negative regulation of cytosolic calcium ion concentration [ISO]
- negative regulation of heart contraction [ISO]
- negative regulation of striated muscle contraction [ISO]
- neurotransmitter uptake [ISO]
- potassium ion import [ISO]
- potassium ion transport [IDA]
- regulation of blood pressure [ISO]
- regulation of cardiac muscle cell contraction [IMP]
- regulation of cardiac muscle contraction by calcium ion signaling [IC]
- regulation of muscle contraction [ISO]
- regulation of respiratory gaseous exchange by neurological system process [ISO]
- regulation of smooth muscle contraction [ISO]
- regulation of striated muscle contraction [ISO]
- regulation of the force of heart contraction [ISO]
- regulation of vasoconstriction [ISO]
- relaxation of cardiac muscle [IC]
- response to glycoside [IMP, ISO]
- response to nicotine [IDA]
- sodium ion export from cell [ISO]
- sodium ion transmembrane transport [IDA]
- sodium ion transport [IDA]
- visual learning [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Phosphorylation and Degradation of Tomosyn-2 De-represses Insulin Secretion.
The abundance and functional activity of proteins involved in the formation of the SNARE complex are tightly regulated for efficient exocytosis. Tomosyn proteins are negative regulators of exocytosis. Tomosyn causes an attenuation of insulin secretion by limiting the formation of the SNARE complex. We hypothesized that glucose-dependent stimulation of insulin secretion from β-cells must involve reversing the inhibitory action of ... [more]
J. Biol. Chem. Jul. 07, 2014; 0(0); [Pubmed: 25002582]
Throughput
- High Throughput
Curated By
- BioGRID