BAIT
STXBP5L
LLGL4
syntaxin binding protein 5-like
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
TPM1
Alpha-tm, Tma2, Tmsa
tropomyosin 1, alpha
GO Process (16)
GO Function (5)
GO Component (7)
Gene Ontology Biological Process
- actin filament capping [IDA]
- cardiac muscle contraction [IDA, ISO]
- cellular response to reactive oxygen species [ISO]
- in utero embryonic development [ISO]
- muscle contraction [TAS]
- muscle filament sliding [IDA]
- negative regulation of cell migration [IGI]
- positive regulation of ATPase activity [IDA, IMP]
- positive regulation of cell adhesion [IGI]
- positive regulation of heart rate by epinephrine [ISO]
- positive regulation of stress fiber assembly [IGI]
- regulation of ATPase activity [IDA]
- ruffle organization [IGI]
- sarcomere organization [ISO]
- ventricular cardiac muscle tissue morphogenesis [ISO]
- wound healing [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Phosphorylation and Degradation of Tomosyn-2 De-represses Insulin Secretion.
The abundance and functional activity of proteins involved in the formation of the SNARE complex are tightly regulated for efficient exocytosis. Tomosyn proteins are negative regulators of exocytosis. Tomosyn causes an attenuation of insulin secretion by limiting the formation of the SNARE complex. We hypothesized that glucose-dependent stimulation of insulin secretion from β-cells must involve reversing the inhibitory action of ... [more]
J. Biol. Chem. Jul. 07, 2014; 0(0); [Pubmed: 25002582]
Throughput
- High Throughput
Curated By
- BioGRID