BAIT

TRIM68

GC109, RNF137, SS-56, SS56
tripartite motif containing 68
UPS Project
GO Process (2)
GO Function (3)
GO Component (5)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

VIM

CTRCT30, HEL113, RP11-124N14.1
vimentin
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

TRIM68 negatively regulates IFN-β production by degrading TRK fused gene, a novel driver of IFN-β downstream of anti-viral detection systems.

Wynne C, Lazzari E, Smith S, McCarthy EM, Ni Gabhann J, Kallal LE, Higgs R, Cryan SA, Biron CA, Jefferies CA

In recent years members of the tripartite motif-containing (TRIM) family of E3 ubiquitin ligases have been shown to both positively and negatively regulate viral defence and as such are emerging as compelling targets for modulating the anti-viral immune response. In this study we identify TRIM68, a close homologue of TRIM21, as a novel regulator of Toll-like receptor (TLR)- and RIG-I-like ... [more]

PLoS ONE Jul. 08, 2014; 9(7);e101503 [Pubmed: 24999993]

Throughput

  • High Throughput

Curated By

  • BioGRID