NEDD4
Gene Ontology Biological Process
- T cell activation [IMP]
- adaptive immune response [IMP]
- blood vessel morphogenesis [IGI, IMP]
- endocardial cushion development [IGI, IMP]
- negative regulation of sodium ion transport [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of vascular endothelial growth factor receptor signaling pathway [IDA]
- neuromuscular junction development [IMP]
- outflow tract morphogenesis [IGI, IMP]
- positive regulation of protein catabolic process [IDA, ISO]
- protein K63-linked ubiquitination [ISO]
- protein monoubiquitination [IDA]
- protein ubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA, IMP]
- regulation of dendrite morphogenesis [IMP, ISO]
- regulation of synapse organization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TRAF2
Gene Ontology Biological Process
- activation of NF-kappaB-inducing kinase activity [ISO]
- cellular protein complex assembly [IDA]
- cellular response to nitric oxide [IMP]
- negative regulation of apoptotic process [NAS]
- negative regulation of glial cell apoptotic process [ISO]
- positive regulation of JUN kinase activity [ISO]
- positive regulation of NF-kappaB transcription factor activity [IMP, ISO]
- positive regulation of T cell cytokine production [ISO]
- positive regulation of extrinsic apoptotic signaling pathway [ISO]
- positive regulation of interleukin-2 production [ISO]
- positive regulation of protein homodimerization activity [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- programmed necrotic cell death [IMP]
- protein K63-linked ubiquitination [ISO]
- protein autoubiquitination [ISO]
- protein catabolic process [IMP]
- protein complex assembly [ISO]
- protein heterooligomerization [ISO]
- protein homotrimerization [ISO]
- regulation of JNK cascade [IDA]
- regulation of apoptotic process [ISO]
- regulation of immunoglobulin secretion [IMP]
- signal transduction [IDA]
- tumor necrosis factor-mediated signaling pathway [ISO]
Gene Ontology Molecular Function- CD40 receptor binding [IPI]
- enzyme binding [ISO]
- identical protein binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [ISO]
- sphingolipid binding [ISO]
- thioesterase binding [ISO]
- tumor necrosis factor receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [ISO]
- CD40 receptor binding [IPI]
- enzyme binding [ISO]
- identical protein binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [ISO]
- sphingolipid binding [ISO]
- thioesterase binding [ISO]
- tumor necrosis factor receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
NEDD4 ubiquitinates TRAF3 to promote CD40-mediated AKT activation.
CD40, a member of tumour necrosis factor receptor (TNFR) superfamily, has a pivotal role in B-cell-mediated immunity through various effector pathways including AKT kinase, but the signal transduction of CD40-meidated AKT activation is poorly understood. Here we report that the neural precursor cell expressed developmentally downregulated protein 4 (NEDD4), homologous to E6-AP Carboxyl Terminus family E3 ubiquitin ligase, is a ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID