BAIT
TIAM1
T-cell lymphoma invasion and metastasis 1
GO Process (10)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- Rac protein signal transduction [IMP]
- apoptotic signaling pathway [TAS]
- cell migration [IMP]
- cell-matrix adhesion [IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of Rac GTPase activity [IMP]
- positive regulation of Rho GTPase activity [TAS]
- positive regulation of apoptotic process [TAS]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CSNK1E
CKIepsilon, HCKIE, RP1-5O6.1
casein kinase 1, epsilon
GO Process (12)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- DNA repair [TAS]
- G2/M transition of mitotic cell cycle [TAS]
- Wnt signaling pathway [IBA]
- circadian regulation of gene expression [ISS]
- endocytosis [IBA]
- mitotic cell cycle [TAS]
- peptidyl-serine phosphorylation [IBA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISS]
- protein phosphorylation [IDA, ISS]
- regulation of cell shape [IBA]
- regulation of circadian rhythm [ISS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Degradation of Tiam1 by Casein Kinase 1 and the SCFβTrCP Ubiquitin Ligase Controls the Duration of mTOR-S6K signaling.
T-cell lymphoma invasion and metastasis 1 (Tiam1) is a guanine nucleotide exchange factor that specifically controls the activity of the small GTPase Rac, a key regulator of cell adhesion, proliferation and survival. Here, we report that in response to mitogens, Tiam1 is degraded by the ubiquitin-proteasome system via the SCFbetaTrCP ubiquitin ligase. Mitogenic stimulation triggers the binding of Tiam1 to ... [more]
J. Biol. Chem. Aug. 14, 2014; 0(0); [Pubmed: 25124033]
Throughput
- Low Throughput
Curated By
- BioGRID