BAIT
KLHL40
2310024D23Rik, Kbtbd5
kelch-like 40
GO Process (4)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
PREY
KANK2
AI504612, Ankrd25, BC010245
KN motif and ankyrin repeat domains 2
GO Process (6)
GO Function (0)
GO Component (2)
Gene Ontology Biological Process
- negative regulation of G1/S transition of mitotic cell cycle [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of intracellular estrogen receptor signaling pathway [ISO]
- negative regulation of programmed cell death [ISO]
- negative regulation of stress fiber assembly [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
KLHL40 deficiency destabilizes thin filament proteins and promotes nemaline myopathy.
Nemaline myopathy (NM) is a congenital myopathy that can result in lethal muscle dysfunction and is thought to be a disease of the sarcomere thin filament. Recently, several proteins of unknown function have been implicated in NM, but the mechanistic basis of their contribution to disease remains unresolved. Here, we demonstrated that loss of a muscle-specific protein, kelch-like family member ... [more]
J. Clin. Invest. Aug. 01, 2014; 124(8);3529-39 [Pubmed: 24960163]
Throughput
- High Throughput
Curated By
- BioGRID