BAIT

KLHL40

2310024D23Rik, Kbtbd5
kelch-like 40
GO Process (4)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Mus musculus
PREY

GAPDH

Gapd
glyceraldehyde-3-phosphate dehydrogenase
Mus musculus

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

KLHL40 deficiency destabilizes thin filament proteins and promotes nemaline myopathy.

Garg A, O'Rourke J, Long C, Doering J, Ravenscroft G, Bezprozvannaya S, Nelson BR, Beetz N, Li L, Chen S, Laing NG, Grange RW, Bassel-Duby R, Olson EN

Nemaline myopathy (NM) is a congenital myopathy that can result in lethal muscle dysfunction and is thought to be a disease of the sarcomere thin filament. Recently, several proteins of unknown function have been implicated in NM, but the mechanistic basis of their contribution to disease remains unresolved. Here, we demonstrated that loss of a muscle-specific protein, kelch-like family member ... [more]

J. Clin. Invest. Aug. 01, 2014; 124(8);3529-39 [Pubmed: 24960163]

Throughput

  • High Throughput

Curated By

  • BioGRID