BAIT
KLHL40
KBTBD5, NEM8, SRYP, SYRP
kelch-like family member 40
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
AHNAK
AHNAKRS
AHNAK nucleoprotein
GO Process (3)
GO Function (4)
GO Component (15)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
KLHL40 deficiency destabilizes thin filament proteins and promotes nemaline myopathy.
Nemaline myopathy (NM) is a congenital myopathy that can result in lethal muscle dysfunction and is thought to be a disease of the sarcomere thin filament. Recently, several proteins of unknown function have been implicated in NM, but the mechanistic basis of their contribution to disease remains unresolved. Here, we demonstrated that loss of a muscle-specific protein, kelch-like family member ... [more]
J. Clin. Invest. Aug. 01, 2014; 124(8);3529-39 [Pubmed: 24960163]
Throughput
- High Throughput
Curated By
- BioGRID