Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.


Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Anver S, Roguev A, Zofall M, Krogan NJ, Grewal SI, Harmer SL

Chromatin regulatory proteins affect diverse developmental and environmental response pathways via their influence on nuclear processes such as the regulation of gene expression. Through a genome-wide genetic screen, we implicate a novel protein called X-chromosome-associated protein 5 (Xap5) in chromatin regulation. We show that Xap5 is a chromatin-associated protein acting in a similar manner as the histone variant H2A.Z to ... [more]

EMBO Rep. Aug. 01, 2014; 15(8);894-902 [Pubmed: 24957674]

Quantitative Score

  • -4.204854 [S score]


  • High Throughput

Ontology Terms

  • phenotype: colony size (APO:0000063)
  • phenotype: heat sensitivity (APO:0000147)

Additional Notes

  • 37C, threshold: -2.5 <= S-score >= +2

Curated By

  • BioGRID