BAIT
XAP5
SPCC14G10.06, SPCC1020.12c
xap-5-like protein
GO Process (2)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Schizosaccharomyces pombe (972h)
PREY
REP1
rec16, SPBC2D10.06
MBF transcription factor activator Rep1
GO Process (7)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
- initiation of premeiotic DNA replication [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IEP, IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IEP]
- positive regulation of transcription involved in G1/S transition of mitotic cell cycle [IMP]
- regulation of transcription involved in G1/S transition of mitotic cell cycle [IC, IMP, TAS]
- transcription from RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [NAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IMP]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [NAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IMP]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [IMP]
Schizosaccharomyces pombe (972h)
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.
Chromatin regulatory proteins affect diverse developmental and environmental response pathways via their influence on nuclear processes such as the regulation of gene expression. Through a genome-wide genetic screen, we implicate a novel protein called X-chromosome-associated protein 5 (Xap5) in chromatin regulation. We show that Xap5 is a chromatin-associated protein acting in a similar manner as the histone variant H2A.Z to ... [more]
EMBO Rep. Aug. 01, 2014; 15(8);894-902 [Pubmed: 24957674]
Quantitative Score
- -3.116323 [S score]
Throughput
- High Throughput
Ontology Terms
- phenotype: colony size (APO:0000063)
- phenotype: heat sensitivity (APO:0000147)
Additional Notes
- 37C, threshold: -2.5 <= S-score >= +2
Curated By
- BioGRID