XAP5
Gene Ontology Biological Process
Gene Ontology Molecular Function
MAK10
Gene Ontology Biological Process
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.
Chromatin regulatory proteins affect diverse developmental and environmental response pathways via their influence on nuclear processes such as the regulation of gene expression. Through a genome-wide genetic screen, we implicate a novel protein called X-chromosome-associated protein 5 (Xap5) in chromatin regulation. We show that Xap5 is a chromatin-associated protein acting in a similar manner as the histone variant H2A.Z to ... [more]
Quantitative Score
- -3.387459 [S score]
Throughput
- High Throughput
Ontology Terms
- phenotype: cold sensitivity (APO:0000148)
- phenotype: colony size (APO:0000063)
Additional Notes
- 20C, threshold: -2.5 <= S-score >= +2
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| XAP5 MAK10 | Positive Genetic Positive Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a less severe fitness defect than expected under a given condition. This term is reserved for high or low throughput studies with scores. | High | 2.022 | BioGRID | 957858 |
Curated By
- BioGRID