BAIT

DHDDS

CIT, CPT, DS, HDS, RP59, RP3-476K8.2
dehydrodolichyl diphosphate synthase
Homo sapiens
PREY

LOX

lysyl oxidase
GO Process (2)
GO Function (1)
GO Component (1)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

In vivo interaction between the human dehydrodolichyl diphosphate synthase and the Niemann-Pick C2 protein revealed by a yeast two-hybrid system.

Kharel Y, Takahashi S, Yamashita S, Koyama T

Dehydrodolichyl diphosphate (DedolPP) synthase catalyzes the sequential condensation of isopentenyl diphosphate with farnesyl diphosphate to synthesize DedolPP, a biosynthetic precursor for dolichol which plays an important role as a sugar-carrier lipid in the biosynthesis of glycoprotein in eukaryotic cells. During certain pathological processes like Alzheimer's disease or some neurological disorders, dolichol has been shown to accumulate in human brain. In ... [more]

Biochem. Biophys. Res. Commun. May. 21, 2004; 318(1);198-203 [Pubmed: 15110773]

Throughput

  • Low Throughput

Curated By

  • BioGRID