PRKCQ
Gene Ontology Biological Process
- intracellular signal transduction [IMP, ISO]
- membrane protein ectodomain proteolysis [IDA]
- negative regulation of T cell apoptotic process [ISO]
- negative regulation of insulin receptor signaling pathway [ISO]
- positive regulation of NF-kappaB import into nucleus [ISO]
- positive regulation of NF-kappaB transcription factor activity [IMP, ISA, ISO]
- positive regulation of T cell activation [IMP]
- positive regulation of T cell proliferation [IMP]
- positive regulation of T-helper 17 type immune response [IMP]
- positive regulation of T-helper 2 cell activation [IMP]
- positive regulation of filopodium assembly [ISO]
- positive regulation of interleukin-17 production [IMP]
- positive regulation of interleukin-2 biosynthetic process [IMP]
- positive regulation of interleukin-4 production [IMP]
- positive regulation of protein secretion [ISO]
- positive regulation of stress fiber assembly [ISO]
- protein phosphorylation [IDA]
- regulation of G2/M transition of mitotic cell cycle [ISO]
- regulation of platelet aggregation [IMP]
- regulation of transcription, DNA-templated [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DTX1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Deltex1 promotes protein kinase cθ degradation and sustains casitas B-lineage lymphoma expression.
The generation of T cell anergy is associated with upregulation of ubiquitin E3 ligases including Casitas B-lineage lymphoma (Cbl-b), Itch, gene related to anergy in lymphocyte, and deltex1 (DTX1). These E3 ligases attenuate T cell activation by targeting to signaling molecules. For example, Cbl-b and Itch promote the degradation of protein kinase Cθ (PKCθ) and phospholipase C-γ1 (PLC-γ1) in anergic ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DTX1 PRKCQ | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID