SGS1
Gene Ontology Biological Process
- DNA double-strand break processing [IGI]
- DNA duplex unwinding [IDA]
- DNA topological change [IDA]
- DNA unwinding involved in DNA replication [IDA]
- cellular response to DNA damage stimulus [IMP]
- chromosome organization [IMP]
- double-strand break repair via homologous recombination [IGI, IMP]
- gene conversion at mating-type locus, DNA double-strand break processing [IGI]
- intra-S DNA damage checkpoint [IGI, IMP]
- meiotic DNA double-strand break processing [IGI]
- meiotic chromosome segregation [IMP]
- mitotic sister chromatid segregation [IMP]
- negative regulation of meiotic joint molecule formation [IGI]
- regulation of reciprocal meiotic recombination [IGI]
- replicative cell aging [IMP]
- telomere maintenance [IGI]
- telomere maintenance via recombination [IGI, IMP]
- telomeric 3' overhang formation [IGI]
Gene Ontology Molecular Function
RAD18
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Swi2/Snf2-like protein Uls1 functions in the Sgs1-dependent pathway of maintenance of rDNA stability and alleviation of replication stress.
The Saccharomyces cerevisiae Uls1 belongs to the Swi2/Snf2 family of DNA-dependent ATPases and a new protein family of SUMO-targeted ubiquitin ligases. Here we show that Uls1 is implicated in DNA repair independently of the replication stress response pathways mediated by the endonucleases Mus81 and Yen1 and the helicases Mph1 and Srs2. Uls1 works together with Sgs1 and we demonstrate that ... [more]
Throughput
- Low Throughput
Ontology Terms
- resistance to chemicals (APO:0000087)
- vegetative growth (APO:0000106)
Additional Notes
- Figure 4
- RAD18 deletion reverses increased growth on HU and MMS of sgs1 uls1 double mutant
- genetic complex
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SGS1 RAD18 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -4.58 | BioGRID | 2356293 | |
| RAD18 SGS1 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 297227 | |
| SGS1 RAD18 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 297228 | |
| RAD18 SGS1 | Positive Genetic Positive Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a less severe fitness defect than expected under a given condition. This term is reserved for high or low throughput studies with scores. | High | 0.1519 | BioGRID | 2605046 | |
| RAD18 SGS1 | Positive Genetic Positive Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a less severe fitness defect than expected under a given condition. This term is reserved for high or low throughput studies with scores. | Low | 0.0831 | BioGRID | 560461 |
Curated By
- BioGRID