RNF4
Gene Ontology Biological Process
- cellular response to gamma radiation [ISO]
- cellular response to hydroxyurea [ISO]
- negative regulation of cell death [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein K11-linked ubiquitination [ISO]
- protein K48-linked ubiquitination [ISO]
- protein K6-linked ubiquitination [ISO]
- protein K63-linked ubiquitination [ISO]
- protein autoubiquitination [ISO]
- protein ubiquitination [ISO]
- regulation of kinetochore assembly [ISO]
- regulation of spindle assembly [ISO]
- response to arsenic-containing substance [ISO]
Gene Ontology Molecular Function
SUMO2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Biochemical Activity (Ubiquitination)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Multiple Arkadia/RNF111 Structures Coordinate Its Polycomb Body Association and Transcriptional Control.
The RING domain protein Arkadia/RNF111 is a ubiquitin ligase in the transforming growth factor β (TGFβ) pathway. We previously identified Arkadia as a small ubiquitin-like modifier (SUMO)-binding protein with clustered SUMO-interacting motifs (SIMs) that together form a SUMO-binding domain (SBD). However, precisely how SUMO interaction contributes to the function of Arkadia was not resolved. Through analytical molecular and cell biology, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID