BAIT
JAK2
Fd17
Janus kinase 2
GO Process (80)
GO Function (17)
GO Component (8)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- JAK-STAT cascade [IDA, IMP, ISO]
- JAK-STAT cascade involved in growth hormone signaling pathway [IDA, IMP, ISO]
- STAT protein import into nucleus [IDA]
- activation of JAK2 kinase activity [IDA]
- activation of MAPKK activity [ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [IDA]
- axon regeneration [ISO]
- cell differentiation [IMP]
- cell migration [IBA]
- cellular response to dexamethasone stimulus [IDA]
- cellular response to lipopolysaccharide [IDA]
- cytokine-mediated signaling pathway [IMP, ISO, TAS]
- enzyme linked receptor protein signaling pathway [IDA]
- erythrocyte differentiation [IMP]
- extrinsic apoptotic signaling pathway [IDA]
- growth hormone receptor signaling pathway [ISO]
- histone H3-Y41 phosphorylation [IBA, ISO]
- hormone-mediated signaling pathway [ISO]
- host programmed cell death induced by symbiont [IDA]
- inflammatory response [IBA]
- innate immune response [IBA]
- interferon-gamma-mediated signaling pathway [ISO]
- interleukin-12-mediated signaling pathway [ISO]
- intracellular signal transduction [IDA]
- intrinsic apoptotic signaling pathway in response to oxidative stress [ISO]
- mammary gland epithelium development [IMP]
- mineralocorticoid receptor signaling pathway [ISO]
- myeloid cell differentiation [IMP]
- negative regulation of DNA binding [IDA]
- negative regulation of apoptotic process [IDA]
- negative regulation of cardiac muscle cell apoptotic process [ISO]
- negative regulation of cell proliferation [IMP]
- negative regulation of cell-cell adhesion [ISO]
- negative regulation of heart contraction [ISO]
- negative regulation of neuron apoptotic process [ISO]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA]
- platelet-derived growth factor receptor signaling pathway [ISO]
- positive regulation of DNA binding [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of apoptotic signaling pathway [IMP]
- positive regulation of cell activation [ISO]
- positive regulation of cell differentiation [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of cell-substrate adhesion [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of growth hormone receptor signaling pathway [IMP]
- positive regulation of inflammatory response [ISO]
- positive regulation of insulin secretion [ISO]
- positive regulation of interleukin-1 beta production [ISO]
- positive regulation of nitric oxide biosynthetic process [ISO]
- positive regulation of nitric-oxide synthase biosynthetic process [IDA, ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [IMP]
- positive regulation of phosphoprotein phosphatase activity [ISO]
- positive regulation of protein import into nucleus, translocation [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of tumor necrosis factor production [IDA]
- positive regulation of tyrosine phosphorylation of Stat3 protein [IDA]
- positive regulation of tyrosine phosphorylation of Stat5 protein [IDA]
- protein autophosphorylation [IDA, ISO]
- regulation of cell adhesion [IBA]
- regulation of inflammatory response [ISO]
- response to antibiotic [ISO]
- response to granulocyte macrophage colony-stimulating factor [NAS]
- response to hydroperoxide [ISO]
- response to interleukin-12 [ISO]
- response to lipopolysaccharide [IDA]
- response to oxidative stress [ISO]
- response to tumor necrosis factor [ISO]
- signal transduction [IMP]
- tumor necrosis factor-mediated signaling pathway [ISO]
- tyrosine phosphorylation of STAT protein [IDA, IMP]
- tyrosine phosphorylation of Stat1 protein [ISO]
- tyrosine phosphorylation of Stat3 protein [ISO]
- tyrosine phosphorylation of Stat5 protein [ISO]
Gene Ontology Molecular Function- SH2 domain binding [ISO]
- acetylcholine receptor binding [ISO]
- growth hormone receptor binding [IBA, ISO]
- heme binding [ISO]
- histone binding [ISO]
- histone kinase activity (H3-Y41 specific) [IBA, ISO]
- insulin receptor substrate binding [ISO]
- interleukin-12 receptor binding [IPI]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- peptide hormone receptor binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [IDA, IMP, ISO]
- receptor binding [ISO]
- type 1 angiotensin receptor binding [ISO]
- SH2 domain binding [ISO]
- acetylcholine receptor binding [ISO]
- growth hormone receptor binding [IBA, ISO]
- heme binding [ISO]
- histone binding [ISO]
- histone kinase activity (H3-Y41 specific) [IBA, ISO]
- insulin receptor substrate binding [ISO]
- interleukin-12 receptor binding [IPI]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- peptide hormone receptor binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [IDA, IMP, ISO]
- receptor binding [ISO]
- type 1 angiotensin receptor binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
IL6ST
5133400A03Rik, AA389424, BB405851, CD130, D13Ertd699e, gp130
interleukin 6 signal transducer
GO Process (20)
GO Function (12)
GO Component (12)
Gene Ontology Biological Process
- ciliary neurotrophic factor-mediated signaling pathway [ISO]
- cytokine-mediated signaling pathway [IDA, ISO]
- glycogen metabolic process [IMP]
- interleukin-27-mediated signaling pathway [ISO]
- interleukin-6-mediated signaling pathway [ISO]
- leukemia inhibitory factor signaling pathway [ISO]
- negative regulation of cytosolic calcium ion concentration [ISO]
- negative regulation of interleukin-6-mediated signaling pathway [ISO]
- oncostatin-M-mediated signaling pathway [ISO]
- positive regulation of T cell proliferation [ISO]
- positive regulation of astrocyte differentiation [IMP]
- positive regulation of cell proliferation [IGI, ISO]
- positive regulation of osteoblast differentiation [ISO]
- positive regulation of smooth muscle cell migration [ISO]
- positive regulation of tyrosine phosphorylation of Stat1 protein [ISO]
- positive regulation of tyrosine phosphorylation of Stat3 protein [ISO]
- regulation of Notch signaling pathway [IDA]
- response to cytokine [ISO]
- signal transduction [IDA]
- triglyceride mobilization [ISO]
Gene Ontology Molecular Function- ciliary neurotrophic factor receptor activity [ISO]
- ciliary neurotrophic factor receptor binding [ISO]
- growth factor binding [ISO]
- interleukin-11 binding [IDA]
- interleukin-11 receptor activity [IDA]
- interleukin-6 binding [ISO]
- interleukin-6 receptor activity [ISO]
- interleukin-6 receptor binding [ISO]
- leukemia inhibitory factor receptor activity [ISO]
- oncostatin-M receptor activity [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- ciliary neurotrophic factor receptor activity [ISO]
- ciliary neurotrophic factor receptor binding [ISO]
- growth factor binding [ISO]
- interleukin-11 binding [IDA]
- interleukin-11 receptor activity [IDA]
- interleukin-6 binding [ISO]
- interleukin-6 receptor activity [ISO]
- interleukin-6 receptor binding [ISO]
- leukemia inhibitory factor receptor activity [ISO]
- oncostatin-M receptor activity [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
Gene Ontology Cellular Component
- cell body [IDA]
- ciliary neurotrophic factor receptor complex [ISO]
- cytosol [ISO]
- dendrite [IDA]
- external side of plasma membrane [IDA]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- interleukin-6 receptor complex [ISO]
- membrane [ISO]
- neuronal cell body [IDA]
- neuronal cell body membrane [ISO]
- oncostatin-M receptor complex [ISO]
Mus musculus
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition.
The inhibitory protein SOCS3 plays a key part in the immune and hematopoietic systems by regulating signaling induced by specific cytokines. SOCS3 functions by inhibiting the catalytic activity of Janus kinases (JAKs) that initiate signaling within the cell. We determined the crystal structure of a ternary complex between mouse SOCS3, JAK2 (kinase domain) and a fragment of the interleukin-6 receptor ... [more]
Nat. Struct. Mol. Biol. Apr. 01, 2013; 20(4);469-76 [Pubmed: 23454976]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| IL6ST JAK2 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.832 | BioGRID | 2681555 |
Curated By
- BioGRID