GNB2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HDAC5
Gene Ontology Biological Process
- B cell activation [TAS]
- B cell differentiation [TAS]
- Notch signaling pathway [TAS]
- cellular response to insulin stimulus [NAS]
- chromatin modification [TAS]
- chromatin organization [TAS]
- chromatin remodeling [TAS]
- chromatin silencing [TAS]
- histone deacetylation [IDA]
- inflammatory response [TAS]
- negative regulation of cell migration involved in sprouting angiogenesis [IMP]
- negative regulation of myotube differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of transcription, DNA-templated [TAS]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of gene expression, epigenetic [IMP]
- regulation of myotube differentiation [ISS]
- regulation of protein binding [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Interaction of G-protein βγ complex with chromatin modulates GPCR-dependent gene regulation.
Heterotrimeric G-protein signal transduction initiated by G-protein-coupled receptors (GPCRs) in the plasma membrane is thought to propagate through protein-protein interactions of subunits, Gα and Gβγ in the cytosol. In this study, we show novel nuclear functions of Gβγ through demonstrating interaction of Gβ(2) with integral components of chromatin and effects of Gβ(2) depletion on global gene expression. Agonist activation of ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID