OPTN
Gene Ontology Biological Process
- Golgi organization [ISO]
- Golgi ribbon formation [IBA, ISO]
- Golgi to plasma membrane protein transport [ISO]
- cellular protein localization [IMP]
- cytokine secretion [ISO]
- defense response to Gram-negative bacterium [ISO]
- macroautophagy [ISO]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of receptor recycling [ISO]
- positive regulation of cell proliferation [ISO]
- protein homooligomerization [ISO]
- protein targeting to Golgi [IBA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
OPTN
Gene Ontology Biological Process
- Golgi organization [ISO]
- Golgi ribbon formation [IBA, ISO]
- Golgi to plasma membrane protein transport [ISO]
- cellular protein localization [IMP]
- cytokine secretion [ISO]
- defense response to Gram-negative bacterium [ISO]
- macroautophagy [ISO]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of receptor recycling [ISO]
- positive regulation of cell proliferation [ISO]
- protein homooligomerization [ISO]
- protein targeting to Golgi [IBA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Oligomerization of optineurin and its oxidative stress- or E50K mutation-driven covalent cross-linking: possible relationship with glaucoma pathology.
The optineurin gene, OPTN, is one of the causative genes of primary open-angle glaucoma. Although oligomerization of optineurin in cultured cells was previously observed by gel filtration analysis and blue native gel electrophoresis (BNE), little is known about the characteristics of optineurin oligomers. Here, we aimed to analyze the oligomeric state of optineurin and factors affecting oligomerization, such as environmental ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID