MAP1LC3A
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
OPTN
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- Golgi organization [IMP]
- Golgi ribbon formation [IDA]
- Golgi to plasma membrane protein transport [IMP]
- cell death [TAS]
- defense response to Gram-negative bacterium [IMP]
- macroautophagy [IDA]
- mitotic cell cycle [TAS]
- negative regulation of receptor recycling [IMP]
- protein targeting to Golgi [IMP]
- regulation of I-kappaB kinase/NF-kappaB signaling [IBA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Ubiquitylation of Autophagy Receptor Optineurin by HACE1 Activates Selective Autophagy for Tumor Suppression.
In selective autophagy, receptors are central for cargo selection and delivery. However, it remains yet unclear whether and how multiple autophagy receptors might form complex and function concertedly to control autophagy. Optineurin (OPTN), implicated genetically in glaucoma and amyotrophic lateral sclerosis, was a recently identified autophagy receptor. Here we report that tumor-suppressor HACE1, a ubiquitin ligase, ubiquitylates OPTN and promotes ... [more]
Throughput
- Low Throughput
Additional Notes
- FigS2H
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| OPTN MAP1LC3A | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 679405 | |
| MAP1LC3A OPTN | Protein-peptide Protein-peptide An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments. | High | - | BioGRID | 3625996 | |
| OPTN MAP1LC3A | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | 1101313 | |
| MAP1LC3A OPTN | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | 679373 |
Curated By
- BioGRID