SUMO3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
IRF7
Gene Ontology Biological Process
- MDA-5 signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- cellular response to DNA damage stimulus [TAS]
- cytokine-mediated signaling pathway [TAS]
- establishment of viral latency [TAS]
- innate immune response [TAS]
- interferon-alpha production [ISS]
- interferon-beta production [ISS]
- interferon-gamma-mediated signaling pathway [TAS]
- negative regulation of macrophage apoptotic process [TAS]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- positive regulation of interferon-alpha production [IDA, TAS]
- positive regulation of interferon-beta production [TAS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IMP]
- positive regulation of type I interferon production [TAS]
- regulation of MyD88-dependent toll-like receptor signaling pathway [ISS]
- regulation of MyD88-independent toll-like receptor signaling pathway [ISS]
- regulation of adaptive immune response [IDA]
- regulation of immune response [TAS]
- regulation of monocyte differentiation [TAS]
- regulation of type I interferon production [TAS]
- response to virus [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
- transcription from RNA polymerase II promoter [TAS]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
The chromatin modification by SUMO-2/3 but not SUMO-1 prevents the epigenetic activation of key immune-related genes during Kaposi's sarcoma associated herpesvirus reactivation.
SUMOylation, as part of the epigenetic regulation of transcription, has been intensively studied in lower eukaryotes that contain only a single SUMO protein; however, the functions of SUMOylation during mammalian epigenetic transcriptional regulation are largely uncharacterized. Mammals express three major SUMO paralogues: SUMO-1, SUMO-2, and SUMO-3 (normally referred to as SUMO-1 and SUMO-2/3). Herpesviruses, including Kaposi's sarcoma associated herpesvirus (KSHV), ... [more]
Throughput
- Low Throughput
Additional Notes
- #LPPI
- Fig8, ChIP re-ChIP experiment
- Likely protein-protein interaction
Curated By
- BioGRID