BAIT

SAE1

AOS1, HSPC140, SUA1, UBLE1A
SUMO1 activating enzyme subunit 1
Homo sapiens
PREY

HSPA2

HSP70-2, HSP70-3
heat shock 70kDa protein 2
Homo sapiens

Biochemical Activity (Sumoylation)

An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

Important Role of SUMOylation of Spliceosome Factors in Prostate Cancer Cells.

Wen D, Xu Z, Xia L, Liu X, Tu Y, Lei H, Wang W, Wang T, Song L, Ma C, Xu H, Zhu W, Chen G, Wu Y

Sentrin/SUMO (small ubiquitin-like modifier)-specific proteases (SENPs) have been implicated in the development of prostate cancer. However, due to the low abundance of SUMO-modified proteins and high activity of SENPs, the SUMO substrates affected by SENPs in prostate cancer cells are largely unknown. Here, we identified SI2, a novel cell-permeable SENP-specific inhibitor, by high-throughput screening. Using SI2 as a way of ... [more]

J. Proteome Res. Aug. 01, 2014; 13(8);3571-82 [Pubmed: 25027693]

Throughput

  • Low Throughput

Additional Notes

  • ubc9, Sumo1

Curated By

  • BioGRID