BAIT
ESS1
PIN1, PTF1, peptidylprolyl isomerase ESS1, L000000587, YJR017C
Peptidylprolyl-cis/trans-isomerase (PPIase); specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNAP II large subunit (Rpo21p) C-terminal domain (CTD); associates with phospho-Ser5 form of RNAP II in vivo; regulates phosphorylation of Ser7 within CTD; present along entire coding length of genes; represses initiation of CUTs; required for efficient termination of mRNA transcription and trimethylation of histone H3
GO Process (13)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- histone H3-K4 trimethylation [IGI, IMP]
- negative regulation of histone deacetylation [IMP, IPI]
- negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IGI, IMP]
- positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [IGI]
- positive regulation of chromatin silencing at rDNA [IMP]
- positive regulation of protein dephosphorylation [IDA, IMP]
- positive regulation of transcription from RNA polymerase II promoter [IGI, IPI]
- protein peptidyl-prolyl isomerization [IDA, IMP]
- regulation of phosphorylation of RNA polymerase II C-terminal domain [IDA]
- regulation of transcription involved in G1/S transition of mitotic cell cycle [IMP]
- regulation of transcription involved in G2/M transition of mitotic cell cycle [IMP]
- termination of RNA polymerase II transcription [IGI, IMP]
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
PREY
YNL193W
Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis
GO Process (0)
GO Function (0)
GO Component (0)
Saccharomyces cerevisiae (S288c)
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
The Yeast Ess1 Prolyl Isomerase Controls Swi6 and Whi5 Nuclear Localization.
The Ess1 prolyl isomerase from Saccharomyces cerevisiae and its human ortholog, Pin1, play critical roles in transcription by regulating RNA polymerase II. In human cells, Pin1 also regulates a variety of signaling proteins and Pin1 misexpression is linked to several human diseases. To gain insight into Ess1/Pin1 function, we carried out a synthetic genetic array screen to identify novel targets ... [more]
G3 (Bethesda) Jan. 27, 2014; 0(0); [Pubmed: 24470217]
Quantitative Score
- -0.22 [Confidence Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
Additional Notes
- SGA analysis with bait strain ess1-H164R
Curated By
- BioGRID