ESS1
Gene Ontology Biological Process
- histone H3-K4 trimethylation [IGI, IMP]
- negative regulation of histone deacetylation [IMP, IPI]
- negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IGI, IMP]
- positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [IGI]
- positive regulation of chromatin silencing at rDNA [IMP]
- positive regulation of protein dephosphorylation [IDA, IMP]
- positive regulation of transcription from RNA polymerase II promoter [IGI, IPI]
- protein peptidyl-prolyl isomerization [IDA, IMP]
- regulation of phosphorylation of RNA polymerase II C-terminal domain [IDA]
- regulation of transcription involved in G1/S transition of mitotic cell cycle [IMP]
- regulation of transcription involved in G2/M transition of mitotic cell cycle [IMP]
- termination of RNA polymerase II transcription [IGI, IMP]
Gene Ontology Molecular Function
IML2
Gene Ontology Cellular Component
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
The Yeast Ess1 Prolyl Isomerase Controls Swi6 and Whi5 Nuclear Localization.
The Ess1 prolyl isomerase from Saccharomyces cerevisiae and its human ortholog, Pin1, play critical roles in transcription by regulating RNA polymerase II. In human cells, Pin1 also regulates a variety of signaling proteins and Pin1 misexpression is linked to several human diseases. To gain insight into Ess1/Pin1 function, we carried out a synthetic genetic array screen to identify novel targets ... [more]
Quantitative Score
- 0.6 [Confidence Score]
Throughput
- High Throughput
Ontology Terms
- vegetative growth (APO:0000106)
Additional Notes
- SGA analysis with bait strain ess1-H164R
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| IML2 ESS1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1275 | BioGRID | 2050708 |
Curated By
- BioGRID