Arachidonic acid (AA) is metabolized through three major enzymatic routes, cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 (CYP), to generate bioreactive molecules that regulate vascular function, inflammation, immunity, and cell growth. These pathways function via complex interaction networks of proteins and other molecules, and their dysregulation underlies several human diseases, including high blood pressure, cardiovascular disease, cancer, and chronic inflammatory disorders.

BioGRID curators consulted domain experts (Garret FitzGerald, Robert Murphy) to identify genes involved in arachidonic acid metabolism and related pathways and also used information from Reactome, KEGG and Gene Ontology (GO) annotations. The arachidonic acid pathway (AAP) was curated using sub categories including the cyclooxygenase (COX), lipoxygenase (LOX), cytochrome P450 pathways, celecoxib metabolism, linoleic acid elongation, and arachidonic acid remodeling pathways. As eicosanoid signaling plays an important role in blood pressure regulation (BPR) and vascular tone, an additional gene list was generated for genes involved in regulating blood pressure.

Molecular interactions for the AAP-related genes were manually curated from the scientific literature by BioGRID curators to provide a global context for the AAP, highlighting physical interactions with proteins in other pathways as well as interactions between individual pathway components. This project page allows users to explore the expert-curated AAP and BPR gene sets, as well as any relevant protein interactions, post-translational modifications (PTMs), and chemical interactions.

This curation project is ongoing and will be updated each month. If you notice errors or missing interactions/publications in this dataset, or otherwise wish to contribute to this project, please contact us at support@thebiogrid.org. All AAP and BPR database records are freely available for download from links within this project.