Saccharomyces cerevisiae (S288c)
CTK1
cyclin-dependent serine/threonine protein kinase CTK1, L000000432, YKL139W
Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; required for H3K36 trimethylation but not dimethylation by Set2p; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13
GO Process (7)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- mRNA 3'-end processing [IGI, IMP]
- peptidyl-serine phosphorylation [IDA]
- phosphorylation of RNA polymerase II C-terminal domain [IMP]
- positive regulation of DNA-templated transcription, elongation [IDA]
- positive regulation of transcription from RNA polymerase I promoter [IMP]
- positive regulation of translational fidelity [IMP]
- protein phosphorylation [IDA, IMP, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download Curated Data for this Protein
33997
559292
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- Interactors 899
- Interactions 1,193
- Network
- PTM Sites 5