BioGRID COVID-19 Coronavirus Curation Project
Search BioGRID for SARS-CoV-2 Protein Interactions | Download SARS-CoV-2 and Coronavirus-Related Interactions

Saccharomyces cerevisiae (S288c)

IRE1

ERN1, bifunctional endoribonuclease/protein kinase IRE1, L000000875, YHR079C

Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; role in homeostatic adaptation to ER stress; Kar2p binds inactive Ire1p and releases from it upon ER stress

Kinome Project (Sc)

GO Process (6)

GO Function (5)

GO Component (2)

Gene Ontology Biological Process

endoplasmic reticulum unfolded protein response [IMP]

fungal-type cell wall organization [IGI, IMP]

inositol metabolic process [IMP]

protein homooligomerization [IDA]

protein phosphorylation [IDA]

protein trans-autophosphorylation [IDA]

Gene Ontology Molecular Function

endoribonuclease activity [IDA]
protein homodimerization activity [IDA]
protein kinase activity [IDA]
protein serine/threonine kinase activity [IDA]
unfolded protein binding [IDA, IMP]

Gene Ontology Cellular Component

integral component of endoplasmic reticulum membrane [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

36513

559292

Interactors 548
Interactions 1,024
Network
PTM Sites 5