BAIT
FGFR2
BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25
fibroblast growth factor receptor 2
GO Process (96)
GO Function (5)
GO Component (12)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- angiogenesis [ISS]
- axonogenesis [ISS]
- bone development [ISS]
- bone mineralization [ISS]
- bone morphogenesis [ISS]
- branch elongation involved in salivary gland morphogenesis [ISS]
- branching involved in labyrinthine layer morphogenesis [ISS]
- branching involved in prostate gland morphogenesis [ISS]
- branching involved in salivary gland morphogenesis [ISS]
- branching morphogenesis of a nerve [ISS]
- bud elongation involved in lung branching [ISS]
- cell fate commitment [ISS]
- cell-cell signaling [ISS]
- digestive tract development [ISS]
- embryonic cranial skeleton morphogenesis [IMP]
- embryonic digestive tract morphogenesis [ISS]
- embryonic organ development [ISS]
- embryonic organ morphogenesis [ISS]
- embryonic pattern specification [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- epidermis morphogenesis [ISS]
- epithelial cell differentiation [ISS]
- epithelial cell proliferation involved in salivary gland morphogenesis [ISS]
- fibroblast growth factor receptor signaling pathway [IDA, IGI, IPI, TAS]
- fibroblast growth factor receptor signaling pathway involved in hemopoiesis [ISS]
- fibroblast growth factor receptor signaling pathway involved in mammary gland specification [ISS]
- fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow [ISS]
- fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development [ISS]
- fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow [ISS]
- gland morphogenesis [ISS]
- hair follicle morphogenesis [ISS]
- in utero embryonic development [ISS]
- innate immune response [TAS]
- inner ear morphogenesis [ISS]
- insulin receptor signaling pathway [TAS]
- lacrimal gland development [ISS]
- lateral sprouting from an epithelium [ISS]
- limb bud formation [ISS]
- lung alveolus development [ISS]
- lung development [ISS]
- lung lobe morphogenesis [ISS]
- lung-associated mesenchyme development [ISS]
- mammary gland bud formation [ISS]
- membranous septum morphogenesis [ISS]
- mesenchymal cell differentiation [ISS]
- mesenchymal cell differentiation involved in lung development [ISS]
- mesenchymal cell proliferation involved in lung development [ISS]
- midbrain development [ISS]
- morphogenesis of embryonic epithelium [ISS]
- multicellular organism growth [ISS]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- odontogenesis [ISS]
- orbitofrontal cortex development [ISS]
- organ growth [ISS]
- organ morphogenesis [ISS]
- otic vesicle formation [ISS]
- outflow tract septum morphogenesis [ISS]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of MAPK cascade [IMP]
- positive regulation of Wnt signaling pathway [ISS]
- positive regulation of canonical Wnt signaling pathway [ISS]
- positive regulation of cardiac muscle cell proliferation [ISS]
- positive regulation of cell cycle [ISS]
- positive regulation of cell division [ISS]
- positive regulation of cell proliferation [IDA, IGI, IMP]
- positive regulation of epithelial cell proliferation [ISS]
- positive regulation of epithelial cell proliferation involved in lung morphogenesis [ISS]
- positive regulation of mesenchymal cell proliferation [ISS]
- positive regulation of phospholipase activity [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- post-embryonic development [ISS]
- prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis [ISS]
- prostate epithelial cord elongation [ISS]
- prostate gland morphogenesis [ISS]
- protein autophosphorylation [IDA]
- pyramidal neuron development [ISS]
- regulation of ERK1 and ERK2 cascade [ISS]
- regulation of branching involved in prostate gland morphogenesis [ISS]
- regulation of cell fate commitment [ISS]
- regulation of fibroblast growth factor receptor signaling pathway [ISS]
- regulation of morphogenesis of a branching structure [ISS]
- regulation of multicellular organism growth [ISS]
- regulation of osteoblast differentiation [TAS]
- regulation of osteoblast proliferation [TAS]
- regulation of smooth muscle cell differentiation [ISS]
- regulation of smoothened signaling pathway [ISS]
- reproductive structure development [ISS]
- skeletal system morphogenesis [TAS]
- squamous basal epithelial stem cell differentiation involved in prostate gland acinus development [ISS]
- ureteric bud development [ISS]
- ventricular cardiac muscle tissue morphogenesis [ISS]
- ventricular zone neuroblast division [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SRC
ASV, SRC1, c-SRC, p60-Src, RP5-823N20.1
SRC proto-oncogene, non-receptor tyrosine kinase
GO Process (50)
GO Function (17)
GO Component (10)
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- Ras protein signal transduction [TAS]
- T cell costimulation [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- bone resorption [IBA, ISS]
- cell adhesion [IBA]
- cellular response to peptide hormone stimulus [IBA]
- cellular response to progesterone stimulus [ISS]
- central nervous system development [IBA]
- epidermal growth factor receptor signaling pathway [IBA, TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [IBA, TAS]
- integrin-mediated signaling pathway [IMP]
- intracellular estrogen receptor signaling pathway [IBA]
- intracellular signal transduction [IDA]
- leukocyte migration [TAS]
- membrane organization [TAS]
- negative regulation of anoikis [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- negative regulation of focal adhesion assembly [ISS]
- negative regulation of intrinsic apoptotic signaling pathway [IMP]
- negative regulation of mitochondrial depolarization [IMP]
- negative regulation of protein homooligomerization [IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- osteoclast development [IBA]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA]
- platelet activation [TAS]
- platelet-derived growth factor receptor signaling pathway [IBA]
- positive regulation of integrin activation [TAS]
- positive regulation of protein kinase B signaling [IMP]
- progesterone receptor signaling pathway [IBA, ISS]
- protein autophosphorylation [IDA]
- regulation of bone resorption [TAS]
- regulation of caveolin-mediated endocytosis [IMP]
- regulation of cell cycle [IBA]
- regulation of cell proliferation [IBA]
- regulation of cell-cell adhesion [IMP]
- regulation of early endosome to late endosome transport [IMP]
- regulation of epithelial cell migration [IMP]
- regulation of podosome assembly [IBA]
- regulation of vascular permeability [TAS]
- response to interleukin-1 [IMP]
- signal complex assembly [TAS]
- signal transduction [TAS]
- stress fiber assembly [IMP]
- transforming growth factor beta receptor signaling pathway [IMP]
Gene Ontology Molecular Function- SH2 domain binding [IPI]
- SH3/SH2 adaptor activity [TAS]
- enzyme binding [IPI]
- ephrin receptor binding [IPI]
- growth factor receptor binding [IPI]
- heme binding [IDA]
- hormone receptor binding [IBA]
- integrin binding [TAS]
- ion channel binding [IPI]
- kinase activity [TAS]
- non-membrane spanning protein tyrosine kinase activity [IBA, TAS]
- phosphoprotein binding [IPI]
- protein binding [IPI]
- protein kinase activity [IDA, TAS]
- protein tyrosine kinase activity [EXP, IDA, TAS]
- receptor binding [IPI]
- scaffold protein binding [IPI]
- SH2 domain binding [IPI]
- SH3/SH2 adaptor activity [TAS]
- enzyme binding [IPI]
- ephrin receptor binding [IPI]
- growth factor receptor binding [IPI]
- heme binding [IDA]
- hormone receptor binding [IBA]
- integrin binding [TAS]
- ion channel binding [IPI]
- kinase activity [TAS]
- non-membrane spanning protein tyrosine kinase activity [IBA, TAS]
- phosphoprotein binding [IPI]
- protein binding [IPI]
- protein kinase activity [IDA, TAS]
- protein tyrosine kinase activity [EXP, IDA, TAS]
- receptor binding [IPI]
- scaffold protein binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Indirect recruitment of the signalling adaptor Shc to the fibroblast growth factor receptor 2 (FGFR2).
The adaptor protein Shc (Src homology and collagen-containing protein) plays an important role in the activation of signalling pathways downstream of RTKs (receptor tyrosine kinases) regulating diverse cellular functions, such as differentiation, adhesion, migration and mitogenesis. Despite being phosphorylated downstream of members of the FGFR (fibroblast growth factor receptor) family, a direct interaction of Shc with this receptor family has ... [more]
Biochem. J. Dec. 01, 2008; 416(2);189-99 [Pubmed: 18840094]
Throughput
- Low Throughput
Curated By
- BioGRID