BAIT
CDCA3
GRCC8, TOME-1
cell division cycle associated 3
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
WEE1
WEE1A, WEE1hu
WEE1 G2 checkpoint kinase
GO Process (5)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [TAS]
- nucleus [TAS]
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC.
Entry into mitosis requires the activation of cdk1/cyclin B, while mitotic exit is achieved when the same kinase activity decreases, as cyclin B is degraded. Cyclin B proteolysis is mediated by the anaphase promoting complex, or APC, an E3 ligase that is active at anaphase in mitosis through G1. We have identified a G1 substrate of the APC that we ... [more]
Cell Apr. 04, 2003; 113(1);101-13 [Pubmed: 12679038]
Throughput
- Low Throughput
Curated By
- BioGRID