BAIT
MTOR
FRAP, FRAP1, FRAP2, RAFT1, RAPT1
mechanistic target of rapamycin (serine/threonine kinase)
GO Process (30)
GO Function (9)
GO Component (11)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- T cell costimulation [TAS]
- TOR signaling [IMP]
- cell growth [IDA, TAS]
- cellular response to hypoxia [ISS]
- cellular response to nutrient levels [ISS]
- double-strand break repair via homologous recombination [IBA]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- growth [NAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- negative regulation of autophagy [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-serine phosphorylation [IMP]
- phosphatidylinositol-mediated signaling [TAS]
- phosphorylation [IDA]
- positive regulation of gene expression [IMP]
- positive regulation of lipid biosynthetic process [IMP]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of transcription from RNA polymerase III promoter [IMP]
- positive regulation of translation [IDA]
- protein autophosphorylation [IDA]
- protein catabolic process [TAS]
- protein phosphorylation [IDA, IMP]
- regulation of actin cytoskeleton organization [IMP]
- response to amino acid [IDA]
- response to nutrient [NAS]
- response to stress [IMP]
- signal transduction [NAS]
Gene Ontology Molecular Function- RNA polymerase III type 1 promoter DNA binding [IDA]
- RNA polymerase III type 2 promoter DNA binding [IDA]
- RNA polymerase III type 3 promoter DNA binding [IDA]
- TFIIIC-class transcription factor binding [IDA]
- kinase activity [IDA, TAS]
- phosphoprotein binding [IPI]
- protein binding [IPI]
- protein dimerization activity [IBA]
- protein serine/threonine kinase activity [IDA, TAS]
- RNA polymerase III type 1 promoter DNA binding [IDA]
- RNA polymerase III type 2 promoter DNA binding [IDA]
- RNA polymerase III type 3 promoter DNA binding [IDA]
- TFIIIC-class transcription factor binding [IDA]
- kinase activity [IDA, TAS]
- phosphoprotein binding [IPI]
- protein binding [IPI]
- protein dimerization activity [IBA]
- protein serine/threonine kinase activity [IDA, TAS]
Gene Ontology Cellular Component
Homo sapiens
PREY
STAT3
signal transducer and activator of transcription 3 (acute-phase response factor)
GO Process (42)
GO Function (13)
GO Component (7)
Gene Ontology Biological Process
- JAK-STAT cascade [TAS]
- JAK-STAT cascade involved in growth hormone signaling pathway [ISO, ISS]
- acute-phase response [IEP]
- aging [IEP]
- astrocyte differentiation [ISO, ISS]
- cell proliferation [ISO]
- cellular response to hormone stimulus [ISO]
- eating behavior [ISO, ISS]
- eye photoreceptor cell differentiation [ISO, ISS]
- glucose homeostasis [ISO, ISS]
- growth hormone receptor signaling pathway [ISO]
- interleukin-6-mediated signaling pathway [ISO, ISS]
- intracellular receptor signaling pathway [ISO]
- negative regulation of cell death [IMP]
- negative regulation of cell proliferation [ISO]
- negative regulation of glycolytic process [ISO]
- negative regulation of hydrogen peroxide biosynthetic process [IMP]
- negative regulation of neuron death [IMP]
- negative regulation of neuron migration [ISO]
- phosphorylation [ISO, ISS]
- positive regulation of ATP biosynthetic process [IMP]
- positive regulation of Notch signaling pathway [ISO, ISS]
- positive regulation of growth factor dependent skeletal muscle satellite cell proliferation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [ISO, ISS]
- protein import into nucleus [ISO, ISS]
- radial glial cell differentiation [ISO, ISS]
- regulation of mitochondrial membrane permeability [IMP]
- regulation of multicellular organism growth [ISO]
- regulation of transcription from RNA polymerase II promoter [ISS]
- regulation of transcription, DNA-templated [ISO]
- response to cytokine [IDA]
- response to drug [IEP]
- response to estradiol [IEP, ISO]
- response to ethanol [IEP]
- response to organic cyclic compound [IEP]
- response to organic substance [IEP]
- response to peptide hormone [IEP]
- sexual reproduction [ISO, ISS]
- stem cell maintenance [ISO]
- temperature homeostasis [ISO, ISS]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- CCR5 chemokine receptor binding [IPI]
- DNA binding [IDA, ISO, ISS]
- RNA polymerase II repressing transcription factor binding [ISO]
- glucocorticoid receptor binding [IPI]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- protein dimerization activity [ISO, ISS]
- protein kinase binding [ISO, ISS]
- protein phosphatase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [ISO]
- CCR5 chemokine receptor binding [IPI]
- DNA binding [IDA, ISO, ISS]
- RNA polymerase II repressing transcription factor binding [ISO]
- glucocorticoid receptor binding [IPI]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- protein dimerization activity [ISO, ISS]
- protein kinase binding [ISO, ISS]
- protein phosphatase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [ISO]
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
BMPs signal alternately through a SMAD or FRAP-STAT pathway to regulate fate choice in CNS stem cells.
The ability of stem cells to generate distinct fates is critical for the generation of cellular diversity during development. Central nervous system (CNS) stem cells respond to bone morphogenetic protein (BMP) 4 by differentiating into a wide variety of dorsal CNS and neural crest cell types. We show that distinct mechanisms are responsible for the generation of two of these ... [more]
J. Cell Biol. Jun. 09, 2003; 161(5);911-21 [Pubmed: 12796477]
Throughput
- Low Throughput
Curated By
- BioGRID