BAIT
KIT
C-Kit, CD117, PBT, SCFR
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
GO Process (53)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- Fc receptor signaling pathway [IDA]
- Fc-epsilon receptor signaling pathway [TAS]
- Kit signaling pathway [IDA]
- T cell differentiation [ISS]
- actin cytoskeleton reorganization [IDA]
- activation of MAPK activity [IDA]
- cell chemotaxis [IDA]
- cytokine-mediated signaling pathway [IDA]
- dendritic cell cytokine production [ISS]
- detection of mechanical stimulus involved in sensory perception of sound [ISS]
- digestive tract development [ISS]
- embryonic hemopoiesis [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- erythrocyte differentiation [ISS]
- erythropoietin-mediated signaling pathway [ISS]
- fibroblast growth factor receptor signaling pathway [TAS]
- hemopoiesis [TAS]
- immature B cell differentiation [ISS]
- inflammatory response [ISS]
- innate immune response [TAS]
- lamellipodium assembly [ISS]
- male gonad development [IEP]
- mast cell chemotaxis [IDA]
- mast cell cytokine production [IDA]
- mast cell degranulation [IMP]
- mast cell differentiation [ISS, TAS]
- mast cell proliferation [TAS]
- megakaryocyte development [ISS]
- melanocyte adhesion [ISS]
- melanocyte differentiation [ISS, TAS]
- melanocyte migration [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- ovarian follicle development [ISS]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- pigmentation [ISS]
- positive regulation of JAK-STAT cascade [IMP]
- positive regulation of MAPK cascade [IMP]
- positive regulation of phosphatidylinositol 3-kinase activity [TAS]
- positive regulation of phosphatidylinositol 3-kinase signaling [TAS]
- positive regulation of phospholipase C activity [TAS]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- positive regulation of tyrosine phosphorylation of Stat1 protein [IMP]
- positive regulation of tyrosine phosphorylation of Stat3 protein [IMP]
- positive regulation of tyrosine phosphorylation of Stat5 protein [IMP]
- protein autophosphorylation [IDA]
- regulation of cell proliferation [TAS]
- regulation of cell shape [ISS]
- signal transduction [TAS]
- signal transduction by phosphorylation [TAS]
- spermatogenesis [ISS, TAS]
- stem cell differentiation [ISS]
- stem cell maintenance [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PIK3R2
MPPH, MPPH1, P85B, p85, p85-BETA
phosphoinositide-3-kinase, regulatory subunit 2 (beta)
GO Process (24)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- T cell receptor signaling pathway [TAS]
- blood coagulation [TAS]
- cellular glucose homeostasis [ISS]
- cellular response to insulin stimulus [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- leukocyte migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol 3-kinase signaling [IDA]
- phosphatidylinositol biosynthetic process [TAS]
- phosphatidylinositol-3-phosphate biosynthetic process [ISS]
- phosphatidylinositol-mediated signaling [TAS]
- phospholipid metabolic process [TAS]
- positive regulation of transcription factor import into nucleus [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- regulation of autophagy [IMP]
- regulation of small GTPase mediated signal transduction [TAS]
- response to endoplasmic reticulum stress [ISS]
- small GTPase mediated signal transduction [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome.
Many human diseases are associated with aberrant regulation of phosphoprotein signaling networks. Src homology 2 (SH2) domains represent the major class of protein domains in metazoans that interact with proteins phosphorylated on the amino acid residue tyrosine. Although current SH2 domain prediction algorithms perform well at predicting the sequences of phosphorylated peptides that are likely to result in the highest ... [more]
Mol. Cell Proteomics Jul. 01, 2014; 13(7);1705-23 [Pubmed: 24728074]
Quantitative Score
- 0.2 [KD]
Throughput
- High Throughput
Additional Notes
- interaction assayed using fluorescence polarization (FP) measurements using one or more phosphopeptides derived from the bait protein and all or a portion of the purified prey protein
- this results in one or more KD values measured in micromolar (0.2,0.63,0.7,2.08,2.31,2.35,3.72,4.07,6.44,6.55,6.89,6.98,7.93,11.77,14.99,15.23,16.65,17.46,19.97) of which the minimum value representing the highest affinity interaction is reported in the HTP score
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| KIT PIK3R2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID